Atrial Fibrillation in AD Patients

 
   Lead Investigator:    Vladimir Hachinski
   Institution      :    London Health Sciences Centre, Western Ontario U.
   E-Mail           :    lsposato@uwo.ca
   Proposal ID      :    414


   Publications:


1  Riccio P, Sposato LA, Vargas ER, Toledo J, Trojanowski J, Hachinski V
   Atrial Fibrillation in Patients with Neuropathological Diagnosis of Primary Alzheimer's Disease
   Abstract  Neurology,84:SI9-5A and S16.002:1526-1632X,2015,

   PUBLISHED



2  Sposato LA, Vargas ER, Riccio PM, Toledo JB, Trojanowski JQ,  Kukull WA , Cipriano LE, Nucera A, Whitehead SN, Hachinski V
   Milder Alzheimer's disease pathology in heart failure and atrial fibrillation
   Journal Article  Alzheimers Dement,13:770-777,2017,PMC5592781

   PUBLISHED





   Proposal Description:
   With the aim of investigating the clinic-pathologic characteristics of AD patients with AF, we compared AD patients with and without AF in terms of: (1) demographic profiles (2) vascular risk factors (3) vascular comorbidities (3) pathological findings and APOE genotyping and (5) cognitive functions, by interrogating the National Alzheimer???s Coordinating Centre (NACC) database cases with autopsy-based neuropathological diagnoses.  We also aimed to present a series of pathophysiological hypotheses exploring neurogenic mechanisms as potential contributors to the genesis of AF in AD patients.